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抑瘤素M的研究进展 被引量:1

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摘要 抑瘤素M(OnceetatinM)为最近发现的一种在体外可以抑制多种肿瘤细胞及白血病细胞生长的多肽类细胞因子。与白血病抑制因子(Leukemiainhibitaryfactor,LIP)、粒细胞克隆刺激因子(G-CSF)、白介素-6(IL-6)等同属一类细胞因子家族,在蛋白结构、基因组成、受体结构及生物学活性等方面具有许多相似之处。本文重点阐述了OSM的蛋白结构、受体组成、生物学活性及其作用的分子机制。
作者 陈国友
出处 《免疫学杂志》 CAS CSCD 北大核心 1994年第2期71-74,共4页 Immunological Journal
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  • 2Liu J, Grove RI, Vestal RE. Oncostatin M activates low density lipoprotein receptor gene transcription in sterol-repressed liver cells. Cell Growth Differ, 1994, 5(12):1333-1338.
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  • 5J.萨姆布鲁克,EF弗里奇,T曼尼阿蒂斯.分子克隆实验指南.金冬燕,黎孟枫,译.2版.北京:科学出版社,1992:908.
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  • 7Nishihara K, Kanemori M, Yanagi H, et al. Ovcrexpression of trigger factor prevents aggregation of recombinant proteins in Escherichia coli. Appl Environ Microbiol, 2000, 66(3):884-889.
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  • 9Albasanz-Puig A, Murray J, Preusch M, et al. Oncostatin M is expressed in atherosclerotic lesions: a role for Oncostatin M in the pathogenesis of atherosclerosis. Atherosclerosis, 2011, (2):292-298.
  • 10Slaets H, Nelissen S, Janssens K, et al. Oncostatin M reduces lesion size and promotes functional recovery and neurite outgrowth aider spinal cord injury. Mol Neurobiol, 2014, 50(3): 1142-1151.

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