摘要
用绵羊红细胞（ＳＲＢｃ）免疫大鼠，在免疫后第３天至第６天，使用光电比色法检测大鼠海马、下丘脑、丘脑、中脑和脑桥内乙酰胆碱酯酶（ＡＣｈＥ）活性的变化。结果表明，海马和下丘脑中ＡＣｈＥ活性在免疫后第３天至第６天均显著低于对照组；而丘脑、中脑和脑侨内ＡＣｈＥ活性与对照组比较均无明显差异。由此提示：在体液免疫应答期间，海马和下丘脑中ＡｃｈＥ活性降低，亦即以上两脑区中乙酰胆碱（ＡＣｈ）含量可能增加。我们以往的实验说明，中枢ＡＣｈ可调节体液免疫应答。综合两者结果，可以推测在中枢ＡＣｈ与免疫之间存在着相互作用。
Rats were immunized with sheep red blood cells(SRBC). On 3～6 days aftet immunization,the changes of acetvlcholinestetase(AChE)activity in the hippocampus.hypothalamus,thalamus.mesencephalon and pons were de-termined by colorimetry. In the hippocampus and hypothalamus, the AChE activity of the rats injected with SRBC wassignificantly lower than that of the animals injected with saline on 3～6 days after injection. However, there were no marked changes of the AChE activity in the thalamus.mesencephalon and pons on 3～6 day,of post-antigen comparedwith that of con trol an imals.The present study indicates the AChE activity in the hippocampus and hypothalamus de-crease during the immune response,therefore suggesting level of acetylcholine(ACh) in the hippocampus and hypothala-mus may increase during the immune response. Our previous experiments showed ACh in the central nervous system maymodulate humoral immune response, Combining the two study results; we infer the interaction exists between ACh in thecentral nervous system and immune reaction.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1994年第4期232-234,共3页
Immunological Journal
关键词
乙酰胆碱脂酶
海马
下丘脑
免疫应答
Acetylcholinesterase, Acetylcholine, Hippocampus, Hypothalamus, Humoral immune response
