摘要
对成人急性非淋巴细胞白血病(ANLL)和淋巴细胞白血病(ALL)分别用A(H)D和VDD(p)+M方案等诱导治疗,并根据化疗后骨髓白血病细胞减少程度个别化调整,初治ANLL和ALL的完全缓解(CR)率分别为0.8和0.72。及早用含第二线抗白血病药物的方案巩固。中高剂量Ara-C和MTX和ABMT的14例中,11例至今持续CR(CCR)。本方案毒性较大,特别对骨髓抑制显著,强化支持和对症治疗是必要的。
Twenty three consecutive adult patients with acute nonlymphoblastic leukemia(ANLL) and twenty one with acute lymphoblastic leukemia (ALL) underwent induction chemotherapy with cytosine arabinoside(Ara- C) or harringtonine and daunorubicin (AD or HD) ,and vincritine daunorubicin dexamethasone (or prednisone) pluse injection of intrathecal methotrexate (MTX) (VDD + M) respectively, with adjustment for individual patients depending on the decrease in leukemic blasts of bone marrow after chemotherapy. The complete remission(CR) were obtained in 80% ANLL and 72% ALL patients. Consolidation intensive chemotherapy contained mitoxantrone andetoposide (VP16) ,and medium or high Ara-C or MTX followed anologous bone marrow transplantation (ABMT) were treated. 11 out of 14 patients received medium or high Ara - C or MTX are still avile with continuons CR. These results demonstrated that prolonged remission and survival could be achieved with this protocol. The level of toxicity is severe,especially inhibition of marrow hematopoiesis,intensive supporting and symptomatic treatment are necessary.
出处
《兰州医学院学报》
1994年第3期161-163,共3页
Journal of Lanzhou Medical College
