摘要
本文报告经选择性肠系膜下动脉灌注化疗治疗直肠癌36例,均有较好疗效。其中13例虽未进行栓塞,但造影复查见血管阻断,肿瘤缩小,手术时出血减少。作者认为局部给药既能杀死肿瘤细胞又能使小血管内皮变性、坏死,以致闭塞血管。而且,还可刺激瘤周组织引起大量炎症细胞浸润及纤维组织增生,加强对肿瘤的抑制作用,防止癌细胞扩散和转移,从而延长术后生存期。介入治疗直肠癌很有价值,并提出了介入治疗的适应证。
36 patients with cancer of rectum treated by infusion chemotherapy after selective inferior mesenteric arteriography were reported.All patients had good result.A- mong them 13 cases without embolization,showed vascular blockage,decrease in size of tu- mor on follow up angiographies and reduction of bleeding during operation.The authors be- lieved that arterial infusion chemotherapy not only can kill tumor cells hut also resulted in degenerative change of vascular endothelia,necrosis and vascular occlusion.Simultaneously it can also stimulate the tissue in the periphery of tumor to produce inflammatory cell infil- tration and fihroplasia,suppress the grwoth of tumor,prevent the spread of tumor cells and metastasis;thus prolong the survival time.Interventional treatment is of great value to can- cer of rectum.The indications were recommended.
出处
《介入放射学杂志》
CSCD
1994年第4期216-217,共2页
Journal of Interventional Radiology
关键词
直肠肿瘤
介入疗法
动脉灌注
Cancer of rectum
Interventioanl treatment
Infusion chemotherapy
