摘要
肝动脉栓塞微球是80年代国外少数国家开始研究用于治疗中晚期肝癌的新剂型。采用超选导管将微球注入肝动脉末梢,起阻断肝癌血供和在局部缓释药物等双重功能。本综述着重介绍笔者实验室研究的羟基喜树碱,甲氨蝶呤明胶微球和顺铂乙基纤维素微球的大鼠栓塞药效学试验,结果证明该剂型对移植性肝癌的治疗是有显著作用的。
The microspheres (ms) for hepatic arterial embolization is a kind of new dosage forms for treatment of non-resectable hepatocellular carcinoma since last decade in abroad. The microspheres could be introduced through the catheter to the end of the hepatic arteries and thus played double roles of embolization and sustained release of the drug entrapp- ed. This review introdueed the therapeutic effects on transplanted liver cancer of rats by us- ing different kinds of microspheres, such as Hydroxycamptothecin, Methotraxate-gelatin ms and cisplatin ethylcellclose ms, all were studied and approved by the authorial labs.
出处
《介入放射学杂志》
CSCD
1994年第2期93-95,共3页
Journal of Interventional Radiology
关键词
微球
肝动脉栓塞
羟基喜树碱
甲氨蝶呤
肝肿瘤
Embolization of hepatic artery
Liver cancer
Hydroxycamptothecin
Methotraxate
cis-Platin
