摘要
笔者通过对15例不能手术肺癌患者支气管动脉灌注顺铂的血药浓度监测,对靶器官及周围组织的血药浓度——时间曲线进行了分析。结果表明,在支气管动脉灌注过程中,靶器官的血药浓度明显高于周围组织的血药浓度,且靶器官的血药浓度大大超过了顺铂的有效抗癌浓度,为支气管动脉灌注治疗肺癌提供了可靠的理论依据,并对灌注过程中应注意的事项进行了分析,对于指导临床治疗具有重要意义.
Monitoring of cisplatin concentration in blood was done in 15 cases with inoperable lung cancer during bronchial artery infusion.The curve of time drug concentration in blood in target organ and peripheral tissue were analysed.Results showed that the drug concentration in target was evident higher than that in peripheral tissue,and the drug concentration in target organ was much higher than the effective drug concentration,therefore. a reliable theory was given for treatment of lung cancer by bronchial artery infusion.
出处
《介入放射学杂志》
CSCD
1994年第1期30-32,共3页
Journal of Interventional Radiology
关键词
支气管动脉
灌注法
顺铂
血药浓度
肺肿瘤
Bronchial artery
Infusion Location cisplatin drug concentration
