摘要
用正常人肺标本7例,肺鳞状细胞癌标本25例,对其间质中的肥大细胞进行光镜与电镜观察.结果表明,肺鳞癌间质肥大细胞比正常肺组织肥大细胞明显增多(P<0.002),每0.0169mm^2中肥大细胞均数分别为4.74±1.54和2.72±0.77.用Alcian蓝一藏红染色后,正常肺肥大细胞颗粒均为Alcian蓝阳性,而肺癌者则除Alcian蓝阳性外,还有藏红阳性的颗粒.电镜观察,正常肺中肥大细胞颗粒多为卷发状,而肺鳞癌中肥大细胞颗粒则多为细颗粒状,并伴有显著脱颗粒现象.以上提示,肥大细胞表型的变化与微环境有关,在肺癌中肥大细胞增多的同时,出现表型的变化,可能与抗肿瘤机制有关.
Mast cells (MCs) in the strorna of 7 cases of normal lungs and 25 casen of lung squanious cell carcinomas were observed by LM and EM. The indieated that the number of MCs in lung cancers was significantly higher that in nomal (P<0.002),the average concentration per 0.0169 mm: being 4.74 and When strind with Blu-Safranin, MCs in the stroma of in the of ing cancers both blue and red mast cells could be found The that most of mast cell granules in normal lungs were of type where those in lung showed particle - type granules with overt degra was related to MCs indicated that againsttumor growth.
出处
《解剖学杂志》
CAS
CSCD
北大核心
1994年第6期487-491,共5页
Chinese Journal of Anatomy
