摘要
用免疫组化方法观察了P物质(SP)、 生长抑素(SRIF)、 亮啡肽(L-ENK)、 甲啡A肽(M-ENK)在16-24周胎儿下丘脑及腺垂体内的发育与分布.结果表明:在16周胎儿下丘脑已出现(?)SRIF、L-ENK和M-ENK阳性神经元,第三脑室室管膜上皮亦呈阳性染色.下丘脑的变化以16-24周最为明显,在16周阳性细胞多为小神经元,分布疏散,20-24周阳性细胞为梭形和多极神经元,主要分布于室周核、室旁核、视上核及腹内侧核.腺垂体在16周胎儿只有少量L-ENK和M-ENK阳性细胞,而SP与SRIF阳性细胞则在第17周出现,17-24周变化最为明显.对这几种神经肽在人胎发育中的分布变化、功能及与垂体激素分泌与发育的关系进行了讨论.
The development and distribution of substance P (SP), somatostatin (SRIF), leuenkephalin (L-ENK) and Met-enkephalin (M-ENK) in hypothalamus and adenohypophysis were studied on 50 human fetus (16-40 weeks) by using ABC immunohistochemical staining method. The results showed that SP, SRIF, L-ENK and M-ENK positive cells apeared in hypothalamus and ependyma of the third ventricular at the 16th week. These cells were small circular, ellipse or sparsely distributed. In 18-24 weeks, the immunoreactive multipolar of fusiform neurons increased and were stained darker. The positive neurons were distributed in periventricular nucleus, supraoptic nucleus, paraventricular nucleus and ventromedial nucleus of hypothalamus. In adenophypophysis, L-ENK and M-ENK cells appeared at the 16th weeks, and SP and SRIF appeared at the 17th week. In 18-24 weeks, darker immunoreactive stained cells were observed. The results suggest that these neuronic peptides may play a role in the development of hypothalamus and adenohypophysis, and in the release of pituitary hormone in human fetus.
出处
《解剖学杂志》
CSCD
北大核心
1994年第1期6-10,共5页
Chinese Journal of Anatomy
关键词
胚胎
下丘脑
腺垂体
human fetal
hypothalamus
adenohypophysis
