摘要
孕鼠161只随机分组,在孕期第7～11天给实验组分别以500mg(kg.d)(蜈蚣1组)及1000mg/kg.d)(娱蚣2组)的中药蜈蚣煎剂灌胃,至孕期18天记录各组孕鼠和胎鼠的发育情况.结果表明:蜈蚣1、2两组致畸作用明显.死胎,吸收胎比例升高:蜈蚣2组胎鼠和孕鼠的体重均下降,堕胎作用显著,与对照组比较,差异均有非常显著意义(P<0.01).
One hundred and sixty-one pregnant mice were divided into several groups at random. 500 mg/ (kg.d) and 1000 mg (kg.d) scolopendra decoction were daily perfused into the stomach of the mice in Group I and Group II respectively from the 7th to the llth day after pregnancy. The development of the mice in different groups were recorded on the 18th day after pregnancy. The re-sults were as follows: the teratogenic effect on the pregnant mice in Group I and Group II were re-markable. The percentage of the dead embryos and the absorbed embryos were increased. In Group II, the body weight of the pregnant mice and of their embryos were reduced and the abortive ef-fect was obvious. As compared with the control group, the cifference was very significant (P<0.01).
出处
《解剖学杂志》
CAS
CSCD
北大核心
1994年第1期56-59,共4页
Chinese Journal of Anatomy
关键词
敌枯双
蜈蚣
胚胎
致畸作用
N. N'-methylene-bis (2-amino-l. 3. 4. thiadiazoie): Scolopendra. embryo
teratogenic effect
