摘要
本文通过家兔和大鼠心肌梗塞模型及临床心肌梗塞患者探讨了小剂量肝素对心肌梗塞的保护作用及其机理。结果表明;小剂量肝素在对凝血及血流变学影响不大的情况下,可缩小心肌梗塞范围,于临床可减少或缓解心绞痛发作;在大鼠心梗模型及临床研究均发现,小剂量肝素能提高SOD水平,降低血清及缺血心肌组织LPO。因此认为肝素对缺血心肌的保护作用,除与已知的抗凝和非抗凝作用有关外,还可能有清除自由基作用。
There are lots of evidence that heparin is very important in prevention or reduction of incidence of coronary diseases through its influence oa coagulation of Mood.The results of oar experimental and clinical researches indicated that heparin in small doses could reduce the size of ischemia and myocardial infarction, increase the level of SOD and decrease the content of LPO. It conld be concluded that heparin might be beneficial in protecting the heart from the incidence of or reducing the size of myocardial ischemia and infarction.
出处
《白求恩医科大学学报》
CSCD
1989年第5期488-494,共7页
Journal of Norman Bethune University of Medical Science
关键词
心肌梗塞
肝素
保护作用
血流变学
Acute myocardial infarction Heparin in small doses Blood rheology Platelet agglutination 6-keto-PGF_(1x) TXB_2 SOD LPO
