摘要
报道对链脲佐菌素（STZ）诱导的实验性糖尿病大鼠几种重要脏器（肝、肾、心、脑）卵磷脂、脑磷脂中脂肪酸构成的变化。不饱和脂肪酸变化的模式（C18：2n-6，C20：3n-6，C22：5n-3，C22：6n-3增加，C20：4n-6降低）基本相同，改变的先后顺序是肝→心、肾→脑。
Diabetes exerts profound impacts on phospholipid metabolism. This report presents the results of a consecutive study, from 4 days to 2 months after the injection of streptozotocin (STZ), on the variations of fatty acid composition in phosphocholine and phosphoethanolamine in visceral organs (liver, kidney and heart) and brain. In STZ induced diabetic rats, the variation pattern of PUFA, i. e. increase in levels of (n-6) fatty acids (C18: 2, C20: 3) and (n-3)C22: 6, and decrease in level of (n-6)C20: 4 is basically the same. The changes begin from liver, and then heart and kidney, brain lags the last.
出处
《江苏医药》
CAS
CSCD
1994年第1期5-7,共3页
Jiangsu Medical Journal
关键词
糖尿病
不饱和脂肪酸
代谢
STZ rats
PUFA metabolism
Consecutive observation
