摘要
本文提出大型液相色谱分离过程流体轴向扩散系数、吸附相平衡常数和总传质系数参数辨识模型,用惰性物为示踪剂扰动应答实验技术和色谱测量技术测定参数。结果表明:在轴向扩散中,涡流扩散占主导地位;轴向扩散系数随流体流速以及装填密度的增大而增大;相平衡常数比总传质系数有较高灵敏度;葡萄糖果糖的相平衡常数随温度的升高而降低,而总传质系数随流体流速和温度的增大而增大;得到理论流出曲线与实验流出曲线一致的结果。
The paper proposes an identification model of axial dispersion coefficient, phase e-quilibrium constant and lumped mass transfer coefficient in the process of large scale liquid chromatography separation. The parameters are determined by using pulse response experiment technique and liquid chromatography technique. The results show that (1) axial dispersion coefficient increases as the fluid velocity and packing density of fixed bed increase; (2) eddy dispersion is dominant in axial dispersion; (3) the effect of phase equilibrium constants on the chromatographic separation are more sensitive than lumped mass transfer coefficients; (4) phase equilibrium constants decrease as the temperature rises, lumped mass transfer coefficients increase as temperature rises and fluid velocity increases and (5) theoretical elution curves are in good agreement with experiment elution curves.
出处
《化工学报》
EI
CAS
CSCD
北大核心
1994年第5期601-610,共10页
CIESC Journal
关键词
相平衡
传质
液相色谱
分离过程
chromatography, parameter identification, axial diffusion coefficient, phase e-quilibrium, lumped mass transfer coefficient
