摘要
本文用免疫组化方法对３６例食道鳞癌、癌旁上皮及深部浸润癌组织的Ｐ２１蛋白进行半定量检测，以了解基因过量表达情况。结果证明，食道鳞癌组织中存在Ｐ２１蛋白过量表达，其表达强弱与肿瘤的分化程度成正比。
Thirty-six cases of esophageal squamous cell carcinoma were studied by means of immunohistochemical staining with ariti-P21, monoclonal antibody.In comparison between the carcinoma and parcarcinoma tissues and the carcinoma tissue and deeply invasive carcinoma, the expression of the ras oncogene product P21 in carcinoma tiussue was stronger than parcarcinoma tissue and deeply invasive carcinoma (p<0. 001 1 as well. Meanwhile, the higher grade carcinomas had a stronger expression than the lower grade carcinomas (p<0.001).As a result of our study, this methad might be regarded as a way to identify the benign and malignant tumor and migh have a prognostic value in treating carcinoma.
出处
《华西医学》
CAS
北大核心
1994年第1期113-115,共3页
West China Medical Journal
关键词
RAS癌基因
P21
鳞癌
食管肿瘤
ras oncogen product P_(21)
Esophageal squamous cell carcinoma
