摘要
以１×１０￣（－６）的杀球灵拌料饲喂，预防家兔黄艾美耳球虫３×１０￣４个孢子化卵囊的人工感染。结果表明增重显著优于感染对照组（０．０１＜Ｐ＜０．０５），显著抑制卵囊增殖（Ｐ＜０．０１），药物预防保护率达９６．１％。攻虫后的肠道粘膜经扫描电镜观察发现，感染对照组肠粘膜有严重的形态病变；药物预防组肠粘膜仅有轻微的病理形态学变化，但结肠粘膜纵行皱折严重萎缩。作者认为杀球灵预防效果很好，但初步建议连续用药时间不宜过长。
The anticoccidial efficacy of diclazuril was studied in rabbits artificially infectedwith Eimeria flavescens. Each rabbit was inoculated by gavage with 3 0000 sporulatedoocysts with continuous administration at 1× 10￣(-6) in pellet feed compared with thecoutrol.It Proved to be highly efficacious in controlling oocyst output (p<0. 01) and bodyweight gain(0. 01 <p<0.05),and the prevention efficiency was 96.1%。 Observed withscanning electron microscope on intestinalis mucosa,it only showed slight morphology de-form compared with the non-infected.non-medicated controls,but the colonic mucosalridgelike structure seriously atrophied,and Clinical signs were fully prevented.Therefore,it could be concluded that continuous diclazuril medication at 1×10￣(-6) in the feed effica-ciously prevented E. flavescens infection in rabbits. But it was preliminarily suggested thatcontinuous diclazuril medication too long be inappropriate.
出处
《河南农业大学学报》
CAS
CSCD
1994年第1期67-71,共5页
Journal of Henan Agricultural University
关键词
杀球灵
黄艾美耳球虫
预防
兔病
diclazuril
Eimeria flavescens
prevention
pathologic change
