摘要
肿瘤的间质反应在一定程度上反映了宿主抗肿瘤的免疫状态,并和预后有关。非Hodgkin淋巴瘤(NHL)的分类和预后亦涉及肿瘤的间质反应。如Rappaport即根据间质内纤维组织间隔的形状,将NHL分为弥漫型和结节型。本文作者在对中国和澳大利亚NHL患者所做的免疫组织化学比较研究中发现,两国患者间存在着病理形态学上的差异。中国组以弥漫型、小裂核细胞和大细胞(裂-无裂)的混合型以及组织细胞性为主,且胞浆内免疫球蛋白(cIg)的检出率较低;澳大利亚组则以结节型居多;瘤细胞内重链和轻链免疫球蛋白(Ig)
Two distinct differences have been detected in the interstitial reaction in a comparative study of non-Hodgkin's lymphoma in Chinese and Australian patients. Most Chinese cases manifest a lack of sclerosis, and a significant absence of florid eosinophil response in lymphoid tissues is often seen in Australian patients with non-Hodgkin's lymphoma. As the interstitial reaction is a response of the host tissue to a certain disease, these differences are thought to be not only of prognostic significance, but also probably due to different environmental or genetic factors.
出处
《实用肿瘤杂志》
CAS
北大核心
1989年第4期216-218,共3页
Journal of Practical Oncology
