摘要
大肠癌是消化道常见的恶性肿瘤,据国外文献对大肠癌超微结构方面的报道不多,且多以实验性大肠癌的动物材料为主,国内迄今有关报道也很少。为进一步了解大肠癌及大肠息肉的超微结构变化,本文报告13例人体大肠癌的超微结构变化,包括透射电镜及扫描电镜的观察,并取人体大肠息肉及正常人体大肠粘膜组织加以比较观察,现将观察结果简要报告如下。材料与方法搜集新鲜大肠癌手术切除标本13例,大肠息肉2例,正常人体大肠粘膜2例,共17例。息肉及正常粘膜作透射电镜观察,13例大肠癌标本均行透射电镜及扫描电镜观察,并给予比较。上述17例同时均取组织块进行常规石腊切片及HE染色,光镜检查。
This article reports the study on 17 freshly-obtained mucosal specimens of the large intes- tine, including 13 surgically-removed carcinoma specimens, 2 polypus specimens and 2 normal specimens. Except for the polypus and normal specimens which were studied only with trans- mission electron microscope (TEM), all the specimens were studied and compared with both TEM and scanning electron microscope (SEM). At the same time, routine paraffin sections for HE stain examination were also made. Of the 13 carcinoma specimens 10 were moderately- differentiated adenocarcinoma, 2 papillary adenocarcinoma and 1 'signet cell, carcinoma. Our observation indicates that ultrastructure of the malignant mucosal cells of the large intestine has morphological features distinct from those of polypus or normal mucosa in the same region, the changes in the nuclei being characteristic, especially in the nucleoli.
出处
《实用肿瘤杂志》
CAS
北大核心
1989年第2期84-87,共4页
Journal of Practical Oncology
