摘要
在原发性高血压(EH)患者、大鼠腹主动脉狭窄和高盐摄入引起高血压模型上,观察到口服牛磺酸治疗4周后均明显降低平均动脉压和收缩压,42.2%的患者血压恢复正常,并能抑制EH患者和高血压大鼠血浆内皮素(ET)、血管紧张素II(AII)水平的升高,增加高血压大鼠血浆降钙素基因相关肽(CGRP)和主动脉组织中的牛磺酸含量.以上结果表明,牛磺酸在降压作用同时伴有缩血管物质的降低和舒血管物质的增加,为以牛磺酸作为降血压辅助药物提供了依据.
Recently some studies showed that taurine (2-Aminoethane sulfonic acid) is the richestfree amino acid in cells, is widely distributed in the body and has profound cytoprotective effect. Taurine can decreases the blood pressure of hypertensive rats treated by DOCA-salt. To prove the antihypertensive action of taurine, we studied the effect of oral taurine (5~6 g/days,4 week) on blood pres-sure and plasma endotgeline (ET) ,angiotensin II (ALL) ,calcitonin gene-related peptide (CGRP) in patients with essential hypertension(EH) and in rats with hypertension. After treatment, the mean arterial pressure and systolic blood pressure were significantly decreased(P<O.05~0.001) and the level ofplasma ET and A II were significantly lower than that in control subjects (P<0.0O1~0.05). However, the level of plasma CGRP in hypertensive rats was significantly increased (38%) as compared withthat in the control group (F<0.05). The level of tissue taurine was increased by 5700 (P<0.001).These data suggested that taurine has an action of antihypertension.
关键词
高血压
牛磺酸
内皮素
血管紧张素
CGRP
<Keyword>Hypertension
Taurine
Endotheline
Angiotensin II
Calcitonin gene-related peptide
