摘要
对氨基苯甲酸酯同系物与细胞色素Ｐ４５０代谢中间体络合物形成速率的定量构效关系傅旭春，刘志强，蒋惠娣（浙江医科大学药学系，杭州，３１０００６）关键词细胞色素Ｐ４５０，对氨基苯甲酸酯，代谢中间体络合物，定量构效关系，分子连接性细胞色素Ｐ４５０是混合功能氧...
The formation rates (v) of cytochrome P450 metabolic intermediate complexes for twelve p-aminobenzoates with untreated or phenobarbital pretreated rat hepatic microsomes were tested. both Hansch's method and molecular connectivity method were used to establish their quantitative structure-activity relationship equations. The significant parabolic correlations between the logarithm values of the formation rates (lgv) and the logarithm values of octanol/water partition coefficients of the p-aminobenzoates (lgP) or their first-order valence molecular connectivity indexes (1χν) were observed.
出处
《高等学校化学学报》
CSCD
北大核心
1994年第12期1807-1809,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
中国医学科学院青年科学基金
关键词
酯
同系物
细胞色素
定量构效关系
Cytochrome P450
p-Aminobenzoates
Metabolic intermediate complex
Quantitative structure-activity relationship
Molecular connectivity
