摘要
铅能抑制卟啉代谢中的某些酶,使其代谢产物如尿ALA,尿粪卟啉(CPU)、FEP等在尿中或血中含量增高。本文对155名铅作业工人做了调查。结果表明,铅接触浓度在均值等于0.036mg/m^3时(铅烟最高允许浓度为0.03mg/m^3),FEP值和对照组比较已有显著差异。FEP和尿ALA,尿铅相关性较好,且较敏感,可作为评价铅早期毒性的重要指标之一。正常人上限定为50μg/dL为宜,建议推广使用。
Lead is capable of restraining some enzymes in porphyrin metabolism and causing an increase of its metabolites in urine or blood, such as urinary δ-aminolevulic acid (ALA-U) , urinary corporphyrin (CP-U) , FEP, etc. One hundred and fifty-five lead-operating workers were investigated, and it was shown that there was a great difference in FEP between the exposure and control groups when the average lead concentration in atmosphere was 0.036mg/m3 (the maximal allowable concentration of lead fume is 0.03mg/ m3) . FEP and ALA or FEP and Pb-U were closely correlated. Thus, FEP may be used as one of the important indexes in evaluating lead intoxication in early stages, and it is worthwhile to be widely popularized. The upper limit for common people is 50μg/dl.
出处
《白求恩医科大学学报》
CSCD
1989年第2期140-142,共3页
Journal of Norman Bethune University of Medical Science
关键词
铅中毒
卟啉
红细胞
生物效应
Lead-operation Exposure level FEP ALA-U CP-U Pb-U Dose-response relationship
