摘要
目的：探讨中枢性心房钠尿肽（ＡＮＰ）与创伤性脑水肿之间的关系．方法：作者利用实验性大鼠脑损伤模型，观察了脑损伤后早期不同时间伤区周围脑组织ＡＮＰ含量变化及其对脑水肿的影响．结果：脑损伤后３０及９０ｍｉｎ，ＡＮＰ含量分别为６．６９±１．３７ｎｇ／ｇ和７．３１±１．００ｎｇ／ｇ，其平行对照值为８．２２±０．２８ｎｇ／ｇ和８．６６±３．４１ｎｇ／ｇ，明显低于正常（８．７６±０．４８ｎｇ／ｇ）和（或）对照值（Ｐ＜０．０５）．伤后３０ｍｉｎ侧脑室内应用ｒＡＮＰⅢ，可用效地防止伤区脑组织水和Ｎａ＋，Ｃａ２＋含量增多．结论：脑损伤后中枢性ＡＮＰ减少与脑水肿形成的病理生理过程可能有关，侧脑室内应用ＡＮＰ具有改善创伤性脑水肿的作用．
Objective:The aim of this study is to investigate the relationship between the central atrial natri-uretic peptide (ANP )and brain edema.Methods:By using rat model with traumatic brain injury,the con-tents of ANP in the injured brain area and periinjuried area were assayed and the effects of ANP on traumatic brain edema caused by brain injury during early stages were observed.Results:The results showed,30～90 min after brain injury,the contents of ANP in the injuried brain tissue were 6.69±l.37 ng/g and 7.31±1.00 ng/g,which were below the normal level (8.76±0.48 ng/g) and/or control level(8.22±0.28 ng/g and 8.66±3.41 ng/g).Early intracerebralventricular administration of rANPⅢ could effectively reduce the con-tents of water and Na+ and Ca2+ in the injured brain tissue. Conclusions: The results indicated that central ANP is closely related with brain edema caused by pathogenic agents.The intracerebral ventricular adminis-tration of ANP may have some relieving effect on traumatic brain edema.
出处
《第四军医大学学报》
1994年第3期200-202,共3页
Journal of the Fourth Military Medical University
关键词
心房钠尿肽
脑水肿
颅脑损伤
brain injury
atrial natriuretic peptide
brain edema
blood brain barrier
