摘要
以豚鼠为对象，向其胆囊内植入人胆固醇及胆色素结石各一块，用低、中、高三种剂量及ＵＤＣＡ治疗一月。结果显示：１．中剂量金石散和ＵＤＣＡ均具有明显溶解胆固醇结石的作用，两者效应相仿，比中剂量大一倍的高剂量溶石效应稍有增加，而低剂量则不显溶石作用。２．对胆色素结石三种剂量金石散均具明显溶石作用，ＵＤＣＡ则无。３．低剂量金石散和ＵＤＣＡ显示具有明显利胆作用。４．动物喂金石散后，胆汁中胆汁酸含量明显升高而胆红素含量显著降低，这可能与金石散的溶石机制有关。
The implanted humen biliary stones were dissoluted with Jin Shi San treatment once a day per oral for one month. 2. The cholelithilytic effect of UDCA and middle dosage of Jin Shi San on cholesterol stone was significant and nearly as same, but the effecacy only increased slightly with duple amount of Jin Shi San used as a higher dosage, while no effecacy with its. lower dosage. 3. The cholelithilytic effect on pigment stone dissolution was all obviously with either the 3 dosages of Jin Shi San, but no effecacy was observed with UDCA. 4. The choleretic action was both significant as treated with UDCA or lower dosage of Jin Shi San. 5. The content of bile acid was raised and bilirubin was reduced obviously after treated with Jin Shi San, and it may be the mechanism of gallstone dissolution.
关键词
金石散
胆结石
胆石
溶解
药理
gallstone dissolution
UDCA
'Jin Shi San'
pigment stone
chlesterol stone
bile acid
bilirubin
