摘要
1983年9月至1988年4月间80例经组织学或细胞学证实的小细胞型肺癌,用CAV-CCNU方案(环磷酰胺、阿霉素、长春新碱、环己亚硝脲)化疗。其中42例加用局部放疗,9例加用头颅 预防性照射。结果32例获C R,33例获P R,完全缓解率40％,总缓解率81.3％,与文献报告结果相似 全组治疗后中位生存期11个月,局限期与广泛期分别为15个月及10个月。治疗后取得完全缓解者中数生存期16个月,较治疗失败者生存期有所改善。一年生存率38.4％,二年生存率11.3％。治疗不能取得C R或P R者无1例存活1年以上。大部份病例治疗后曾发生白细胞减低及脱发,1例死于严重感染,其余均能耐受。本文材料证明以化学治疗为主的综合治疗对小细胞肺癌病人改善预后确有一定帮助,但长期存活者仍少见。
During the peiod Sept 1983 through Apr 1988.80 cases of Small Cell Lung Cancer (SCLC) were treated with CAV-CCNU chemotherapy. In 42 local^adiotherapy, and in 9 prophylactic cranial irradiation were added to the treatment protocols. Results of treatment: CR 32 cases (40%), PR 33 cases, Total Response rate 81.3%. MST for the whole group was 11m., 15m. and 10m. for limited stage and extensive stage patients respectively. MST of those achieved CR was 16m., which was better than the induction failures. 1 year survival rate 38.4%, 2 year survival rate was 11. 3 %.Most of the cases survived leucopenia and Alopecia following chemotherapy, only l died of severe infection. This paper confirmed the value of intensive chemotherapy combined with other treatment modalities in improving the prognosis of SCLC however, only around 10% of the cases may achieve long term survival.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第2期101-103,共3页
Chinese Journal of Cancer
