摘要
三氯化铝催化下的酚类化合物芳环酰化反应,是一个傅-克反应和傅瑞斯重排反应的竟争反应。在反应初期,傅-克反应占据主导地位;在反应后期,傅瑞斯重排反应占据主导地位。另外,通过理化性质,光谱数据和化学相关法,四个新化合物的结构也分别被确定为:2-羟基-3-甲基-4-甲氧基-6-丁酰氧基苯甲酸甲酯(Ⅵ),2-丁酰氧基-3-甲基-4-甲氧基-6-羟基苯甲酸甲酯(Ⅶ),2,4-二甲氧基-3-甲基-6-丁酰氧基苯甲酸甲酯(Ⅷ),4,6-二甲氧基-2-丁酰氧基-3-甲基苯甲酸甲酯(Ⅸ)。
Aluminum halide-catalyzed benzoylation reaction of phenols is a competitiveprocess between Friedel-Crafts and Fries rearrangement reaction. In the early partof the reaction Friedel=Crafts reaction is dominant, whereas in the latter halfFries rearrangement is dominant. Four novel compounds were also elucidated bymeans of physicochemical properties, spectroscopy and chemical correlation. Theyare methyl 2-hydroxy-3-methyl-4-methoxy-6-(1-oxobutoxy)-benzoate (Ⅵ), me-thyl 2-(1-oxobutoxy)-3-methyl-4-methoxy-6-hydroxy-benzoate(Ⅶ), methyl 2, 4-dimethoxy-3-methyl- 6-(1-oxobutoxy)-benzoate (Ⅷ) and methyl 4, 6-dimethoxy-2-(1-oxobutoxy)-3-methyl-benzoate (Ⅸ).
关键词
酚酮
芳环酰化反应
三氯化铝
Friedel-Crafts reaction
Fries reaction
Methyl 2-hydroxy-3-methyl-4-methoxy-6-(1-oxobutoxy)-benzoate
Methyl 2-(1-oxobutoxy)-3-methyl-4-methoxy-6-hydroxy-benzoate
Methyl 2, 4-dimethoxy-3-methyl-6-(1-oxobutoxy)-benzoate
Methyl 4, 6-dimethoxy-
