摘要
本文在提纯妊娠相关血浆蛋白Ａ（ＰＡＰＰ－Ａ）的基础上，研制ＰＡＰＰ－Ａ单向免疫扩散法，对正常妊娠２０～４０孕周３３５例，高危妊娠９８例血清ＰＡＰＰ－Ａ值进行了测定，结果表明正常妊娠孕妇血中ＰＡＰＰ－Ａ水平在２０孕周后随孕周的增加而增加，直至分娩，轻、中度妊高征者５５．６％的患者血ＰＡＰＰ－Ａ分布在均值以上，重度妊高征有６０．７％的患者血ＰＡＰＰ－Ａ水平分布在正常范围的上限上下。胎儿宫内发育迟缓有５６．２％孕妇血清ＰＡＰＰ－Ａ水平接近或低于同孕周正常值下限。而死胎及无脑儿时ＰＡＰＰ－Ａ无明显变化。
On the basis of purifying pregnancy associated plasma protein A(
PAPP-A),PAPP-A single radial immunodifussion(SRID) was studie.Serum PAPP-A levels were
deter-mined by PAPP-A-SRID method in 335 cases with normal pregnancy and 98 cases with
high-risk pregnancy.The results showed that serum PAPP-A levels in the normal pregnancy
in-creased with advance of gestational week after the 20th week, up to delivery. In mild and
moder-ate hypertension of pregnancy (PIH), 55.6%PAPP-A values were distributed above the
normalmean, while in sereve PIH, 60.7%about the upper limit of the normal range. In
intrauterinegrowth retardation(IUGR), 56. 2%serum PAPP-A valuse were close to or less than
the normallower limit of the same gestational week.Serum PAPP-A levels were not significantly
changed instillbirth and anencephalus.
出处
《白求恩医科大学学报》
CSCD
1994年第1期50-52,共3页
Journal of Norman Bethune University of Medical Science
关键词
妊娠
血液
妊娠毒血症
蛋白A
pregnancy/BL
pregnancy
toxemias/BL
pregnancy proteins/PH
