摘要
肌注ＭＢ２（２０ｍｇ／ｋｇ、４０ｍｇ／ｋｇ）对小鼠扭体反应和光辐射性疼痛模型均有明显的镇痛作用，其强度（４０ｍｇ／ｋｇ）与乙酰水杨酸（４００ｍｇ／ｋｇ）相当，但较度冷丁（５０ｍｇ／ｋｇ）弱而持久．小鼠连续５日给药后不产生耐受性，与吗啡无交叉耐受性．０．２％的ＭＢ２对家兔角膜反射无影响，但对蝎蜍坐骨神经动作电位有阻滞作用，其强度与１％普鲁卡因相当，弱于１％利多卡因．
Analgesic effect of MB2(20mg/kg,40mg/kg)was shown by intramuscle on the micewrithing caused by HAc and tail-flick response to light irradiation.Their potency and action phasewere similar to those of aspirin(400mg/kg),but much weaker than dolantin(5mg/kg). MB2 intramuscle of 30mg/kg×5d in mice induced neither tolerance(like morphine)nor cross-tolerance withmorphine; There is no obvious influtnce on corneal reflex in rabbits’eyes by MB2; It( 0.2%)blocked the action potential of sciatic nerve in toad. The inhibiting potency was similar to procaine(1%),but much weaker than lidocaine(l%).
出处
《蚌埠医学院学报》
CAS
1994年第2期97-100,共4页
Journal of Bengbu Medical College
关键词
MB2
局部麻醉
抗感染药
止痛
MB2
analgesic effect
tolerance
cross-tolerance
local anesthetic action
