摘要
本文报道测定２１例喉癌和３０例喉良性病变组织的性激素受体（ＳＨＲ）、雌激素受体（ＥＲ），并对２１例喉癌患者手术前后血清性激素水平进行测定及比较。结果表明，喉癌组织存在ＳＨＲ及ＥＲ，其阳性率均为用６１．９％；而喉良性病变组织ＳＨＲ及ＥＲ阳性率仅占６．７％。两者统计学上有非常显著性差异（Ｐ＜０．０００１）。２１例喉癌患者术后血清睾酮水平较术前呈下降趋势，统计学上亦有显著性差异（Ｐ＜０．０１）；而血清雌二醇和孕酮水平术后与术前比较则变化不大。本结果对探讨喉癌的发病机制及内分泌治疗可能有一定参考价值。
The determination of the sex hormone receptors(SHR)and estro-gen receptor (ER) was done in 2l cases of laryngeal carcinoma and 30 cases of benignlaryngeal disease。 The preoperative and postoperative serum sex hormone levels werecompared in 2l laryngeal carcinoma cases。 The existence of sex homone receptor(SHR)and estrogen receptor (ER) was evident in the laryngeal carcinoma tissue, the postitiverate was 6l,9%, however, positive rate of SHR and ER in benign laryngeal disease wasonly 6.7 % The difference was significant statistically (P < 0.01). The changes of serumestrogen and progestin levels is not significant between preoperative and postoperativeperiod The resuIts may be helpful to probe the mechanism of laryngeal carcinoma andendocrino-therapy.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1994年第5期432-434,437,共4页
Chinese Journal of Cancer
关键词
癌
性激素
受体
喉肿瘤
Laryngeal carcinoma Benign laryngeal disease SeX hormone (SH)Sex hormone recptor(SHR)
