摘要
本文测定12例扩张型心肌病伴充血性心力衰竭患者静脉滴注硝酸甘油和多巴酚丁胺的血液动力学及左心室功能变化。硝酸甘油使主动脉、肺动脉和左心室充盈压明显下降,心脏指数增加。多巴酚丁胺并不明显改变主动脉压和肺动脉压,轻度降低左心室充盈压,但显著增加心脏指数。两药均降低血管阻力和增加左心室射血分数。上述部分有益作用在两药合用时尤为明显。
In 12 patients with dilated cardiomyopathy, intracardiac pressure and echocardiography were recorded simultaneously during nitroglycerin and dobutamine infusion. Nitroglycerin reduced arterial, pulmonary and left ventricular filling pressure, and increased cardiac index. Dobutamine did not significantly alter arterial and pulmonary pressure, slightly decreased left ventricular filling pressure, and significantly increased cardiac index. Both agents reduced systemic and pulmonary vascular resistance, and improved left ventricular ejection fraction. Part of the hemodynamic and left ventricular functional changes became more obvious when the two drugs were infused in combination.
出处
《上海医学》
CAS
CSCD
北大核心
1989年第1期12-14,共3页
Shanghai Medical Journal
