摘要
在25只wistar大鼠中用静脉注射高分子右旋糖酐的方法复制微循环障碍模型,用激光多普勒微循环血流计测定肝素治疗对微循环障碍大鼠肾、肝、尾表面血液灌流量的影响。观察到除62.5u/100g Bw肝素治疗组外,在125u及250u/100gBw肝素治疗组中用药后肾血液灌流量明显增加(P<0.05),同时尿量也明显增加,用FITC-Dextran-150做肾内荧光微血管造影的结果证实治疗后肾内有血流重分布,皮质灌流量增加。
An animal model of microcirculatory disturbances was created by intravenous-injection of high molecular weight Devtran. The effects of Heparin on microcirculatory perfusion of kidney, liver and tail was studied with a laser doppler flowmeter in 25 rats. After administration of 125u /100 g Bw in the Heparin group, the renal perfusion significantly increased (P<0.05). Urine volume increased simultanously. Meanwhile, the results of renal microangiography showed a redistribution in renal perfusion and a perfusion increase in the renal cortex following intravenous injection of FITC-Dextran 150.
出处
《上海医科大学学报》
CSCD
1993年第4期281-284,T016,共5页
Journal of Fudan University(Medical Science)
关键词
微循环障碍
肾
血管造影
microcirculatory disturbances
perfusion
kidney
laser doppler flowmeter
fluoresoein microangiography
