摘要
我们测定了42例单纯性肥胖症小儿的肾上腺皮质功能,结果显示:①1/3的患儿血浆总皮质醇(PTC)昼夜节律正常,而其余2/3的患儿存在不同程度、不同类型的异常;②尿游离皮质醇(UFC)的含量在正常范围;③地塞米松抑制筛查试验正常。表明多数单纯性肥胖症患儿的肾上腺皮质功能活动水平较高;但对地塞米松的反馈抑制作用仍十分敏感,与正常小儿及柯兴综合征患者均有显著不同。
The ciroadian rhythm of plasma total oortisol (PTO) levels and urinary free cortisol (UFC) were determined, and the dexamethasone suppressive screening test performed in 42 oases of children with simple obesity, to explore the possibility of any change in regulation of their adrenocortical function. The results showed that: (1) The PTO level at 8am was within normal range in all cases; (2) The oircadian rhythm of PTO was abnormal in extent and type in 27 oases (64.3%), and normal in the remaining 15 cases (35.7%). The oircadian rhythm showed 6 type of manifestations; (3) The UFO and dexamethasone suppregsive screening test were normal in all oases. These indicate that the adrenocortioal function in most of the children with simple obesiby was hyperactive, but highly sensitive to the negative feed-back suppressive effect of dexamethasone. The difference in adrenocortical function in oases of simple obesity from that in normal children and children with Cuahiag's syndrome is discussed.
出处
《上海医科大学学报》
CSCD
1989年第6期459-462,共4页
Journal of Fudan University(Medical Science)
关键词
肾上腺皮质
肥胖症
儿童
adrenocortical function
children
simple obesity
