摘要
应用高效液相色谱法分析尿中2-硫代噻唑烷-4-羧酸(TTCA)。54名非接触者的结果示个体差异较大,频数分布呈明显偏态,几何平均水平约0.06mg/g肌酐。9名非接触者的动态观察表明,同一个体有时检出、有时检测不出,每天排泄总量平均0.046mg,未见明显规律。接触二硫化碳工人班前尿TTCA排泄特征与非接触者一样,几何平均水平0.08mg/g肌酐;不同接触水平者次日班前尿、工作周连续每日班前尿TTCA均无明显差异,提示尿TTCA无蓄积性,接触后16h能完全排出体外;接触者班未尿TTCA明显上升,呈现群体接触效应关系。取生物监测临界值0.3mg/g肌酐,尿TTCA反映二硫化碳接触特异度、敏感度和阳性预测值分别是87％、84％和86％。可用于二硫化碳接触的群体生物监测。
Urinary 2-thiothiazolidine-4-carboxylie aoid (TTOA) was measured by HPLC In non-exposed and oarbon-disulfiede exposed subjects. In the non-exposed TTOA levels were low and fluctuating. After exposure, TTOA is rapidly excreted and has reached its original levels by next morning. -A correlation between exposure and TTOA excretion in terms of employer groups working under different concentration levels was obtained. Setting 0.3 mg/g oreatinine as a criterion for discriminating exposure, the sensitivity (84%), specificity (87%) and positive predictive value (86%) for such screening was found to be satisfactory. The applicability and usefulness for monitoring exposure to carbon disulfide was verified.
出处
《上海医科大学学报》
CSCD
1989年第6期449-453,共5页
Journal of Fudan University(Medical Science)
关键词
二硫化碳
TTCA
生物监测
尿
carbon disulfide
2-thiothiazolidine-4-carboxylic acid
biologicalmonitoring
