摘要
作者用人羊水肺表面活性物质(PS)治疗一例肺透明膜病取得成功。PS剂量为150mg磷脂/kg,从气管插管一次滴入。临床症状,经皮测氧(TcPO_2)和吸入氧浓度(FiO_2)24h后明显好转,气道吸出物中的卵磷脂/鞘磷脂(L/S)比值、磷脂酰甘油(PG)和最低表面张力(γmin)逐渐恢复。肺部X线片原示毛玻璃样改变,PS治疗后3d明显改善,第6天病情基本恢复,最后痊愈出院。
A case of hyaline membrane disease was treated successfully with pulmonary surfactant (PS) we had isolated from human amniotio fluid. The exogenous PS was instilled via a tracheal cannula in a stogie dose of 150mg phospholipid/kg. 24 hours after the administration of PS, clinical symptoms, transoutaneous partial pressure of oxygen (ToPO2) and fractional inspired oxygen concentration (FiO2) were significantly improved. The leoithin/sphingomyelin (L/S) ratio, phosphotidylgly-cerol (PG) and minimal surface tension (γmin) of traoheal aspirates gradually became normal. The radiologio finding 'ground glass appearance' .in the lung fields showed striking improvement 3 days after PS treatment. The diseased condition was stabilized on the sixth day. She was eventually discharged with complete recovery.
出处
《上海医科大学学报》
CSCD
1989年第2期151-153,共3页
Journal of Fudan University(Medical Science)
关键词
肺透明膜病
人羊水PS
替代治疗
hyaline membrane disease
pulmonary surfactant
replacement therapy
