摘要
作者报告利用17只兔胎仔于妊娠24～25天行子宫内胎儿外科手术,制作成尿路梗阻、羊水过少模型。通过对胎仔大体形态学观察和形态学测量,发现实验组羊水明显减少,兔胎仔大体形态也较对照胎仔瘦小,体重、肺重及肺重占体重的百分比也显著降低。提示羊水过少对胎仔发育具有明显影响,导致胎儿宫内生长迟缓和肺发育不全。
A model of similar urethral obstruction was developed by ligatting bladder outlet and uraclius at 24 -25 days gestation in 17 fetal rabbits. In experimental group,it produced severe bilateral hydronephrosis and oligohydramnios (amniotic fluid volume reduced, P<0.01). Macroscopic examination shows that rabbit fetus body was smaller in experimental group than control. The experimental group had sighificantly decreased total body weight,lung weight,and de- creased lung weight -to-body weight ratios compared to control(P<0. 01). It suggests that fetal urethral obstruction has far—reaching effects on the development of the fetus. Without adequate fetal urine output,amnitic fluid volume decreases resulting in fetal intrauterine growth retardation and pulmonary hypoplasia.
出处
《合肥医学院学报》
1993年第3期7-10,85,共4页
Journal of Zunyi Medical University
基金
贵州省卫生厅基金
关键词
羊水过少
胎儿
生长发育
胎儿外科
oligohydramnios
growth
development
fetal
fetal surgery
rabbit
