摘要
以基因重组白细胞间介素Ⅱ(rIL-2)诱导肝癌患者自体脾LAK细胞,经肝动脉,辐注。自体LAK细胞10~9×2,rIL-2 5×10~4u×2连续低剂量经肝动脉导管输注一个疗程。治疗连续观察血清AFP变化及肝功能变化。用B超、CT观察肿块变化,结果显示:本组3例治疗后血清AFP均连续下降,B超、CT显示肿块缩小。患者主观症状好转,肝功能有所恢复。自体LAK细胞输注后仅有一过性发热。
The autologous splenic lymphokine activated killer(LAK)cells induced by recombinant IL-2 (rIL-2) were infused via hepatic artery as well as systemically in the treatment of primary hepatic carcinoma. 10~9×2 autologous LAK cells and 5×10~4u×2rIL-2 were infused through hepatic artery continuously for 5 days as one course of treatment. During the treatment period,levels of AFP in serum and hepatic function were monitored. The size of the tumor was also observed by successive B-ultrasound and CT. All the three patients showed Steady decline of AFP levels,reduction of tumor bulk,and improvement of liver function and symptoms. Transient fever after the infusion of autologous LAK cells was ex- perienced in the patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1993年第9期649-652,共4页
Chinese Journal of Clinical Oncology
关键词
脾
自体
癌
肝肿瘤
杀伤细胞
LAK cells
Autologus splenic LAK cells
Primary hepatic carcinoma
Hepatic artery infusion
Treatment
