摘要
首次应用中药延胡索的生物碱——左旋四氢巴马汀(即颅通定)口服治疗心房颤动(房颤),以动态心电图或心电遥测技术评定疗效,结果显示:对阵发性房颤有效率81.8%,持续性房颤有效率43.0%,其抗房颤机理与该药延长心房和房室结有效不应期有关。分析了影响药物疗效的因素和药物对血压、心率的作用。该药无严重副作用。表明颅通定是一种治疗房颤安全有效的药物。
L-tetrahydropalmatine (Rotundium) is an alkaloid of Corydalis turtschaninovii. Some animal
experiments had demonstrated that Rotundium had a good antiarrhythmic effect in blocking the
calcium channel and that it was a class Ⅳ antiarrhythmic agent, similar to that of Bepridil in
literatures. This is a clinical report of Rotundium (oral given) on an atrial fibrillation (AF) patients.
The therapeutical results were evaluated by 24 hours ambulatory electrocardiographic monitoring
and ECG. The results showed that the effective rate of Rotundium on paroxysmal atrial fibrillation
and sustained atrial fibrillation of 45 mm (left atrium diameter) or more was 30%, while LAD of less
than 45mm was 80% (P<0.01). Among 8 cases duration of AF were 6 months or more, 3 cases were
effective, the effective rate 37.5%, while among 10 cases' duration of AF were less than 3 weeks, 3
cases were converted to sinus rhythm, 5 cases were effective. There was a significant difference
between two groups. Age and sex exerted no effect on efficacy. During taking Rotundium, blood
pressure had no apparent changes and no severe side effects were found. The results showed that
Rotundium is an effective, safe new drug to treat AF, especially in paroxysmal atrial fibrillation.
The antiarrhythmic mechanism of Rotundium might be related to its prolonging of the effective
refractory period of atrial and atrioventricular node.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1993年第8期455-457,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
颅通定
钙拮抗剂
延胡索
心房颤动
L-tetrahydropalmatine
Rotundium
atrial fibrillation
ambulatory electrocardiographic monitoring
calcium antagonist
