摘要
加味炙甘草汤注射液预防组与生理盐水组比较可使乌头碱所致室早性早搏(PVCs)和室性心动过速(VT)发生率明显降低(P<0.01)。使氯化钙(CaCl_2)所致PVCs和VT发生率显著降低,P值分别小于0.01和0.05。其出现时间明显推迟,P值分别小于0.05和0.01。窦性心律恢复时间明显提前(P<0.01),复律率显著提高(P<0.05)。治疗组与生理盐水组比较,首次给药窦性心律短时转复率有显著差异(P<0.01),3次给药后窦性心律转复率明显提高(P<0.01),表明加味炙甘草汤注射液有很好的抗乌头碱和CaCl_2所致室性心律失常的作用。
The antiarrhythmic effect of Jiawei Zhigancao Tang injection (JZTI) was studied in experimen-tal arrhythmia induced by aconitine or by CaCl_2 in anesthetized rats. The prophylactic dose of JZTI(5g/kg, iv.) reduced the incidence rate of premature ventricular complexes, ventricular tachycardia(P<0.01), delayed the onset time of arrhythmia induced by CaCl_2 (P<0.01), and the recovery timeof sinus rhythm occurred earlier than that of control group (P<0.01). The therapeutic dose of JZTI(10g/kg, iv.) raised the rate of aconitine-indued arrhythmia to sinus rhythm conversion (P<0.05).The results showed that JZTI could significantly antagonize arrhythmia induced by aconitine or byCacl_2 in rats.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1993年第7期423-425,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
加味灸甘草汤
针剂
心律失常
Jiawei Zhigancao Tang Injection
aconitine
CaCl_2
arrhythmias
