摘要
应用黑色根霉静息细胞系统中的添加物,对16,17α-环氧黄体酮的羟化反应的影响进行了研究,经正交设计等方法的试验与分析,得知葡萄糖、核黄素、Mg^(2+)、Fe^(2+)对羟化反应有明显影响。反应体系中加入0.4%葡萄糖、0.01%核黄素、0.3%Mg^(2+)和0.2% Fe^(2+)可提高羟化反应的转化率。
The effect of various additives on 11α-hydroxylation of 16,17α-epoxyprogesterone using Rhizopus nigricans resting cell system was studied andit was found that addition of 0.4% glucose,0.01% riboflavin,0.3%Mg^(2+) and Fe^(2+)to the medium the hydroxylation could be promoted.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1993年第8期343-345,共3页
Chinese Journal of Pharmaceuticals
关键词
黑色根霉
甾体激素
羟化反应
Rhizopus nigricans
steroid
11α-hydroxylation
