摘要
本实验以大鼠为研究对象,用放射免疫法测定脑组织的P物质(SP)含量,用脾脏空斑形成细胞(PFC)技术作为反映绵羊红细胞(SRBC)引起的体液免疫反应状态的指标,对部分脑区SP在神经免疫调节(NIM)中的作用进行了研究。结果显示,在SRBC引起的免疫反应高峰期大鼠下丘脑、海马及脑桥的SP含量明显降低,而垂体、中脑及延髓的SP含量未见明显改变,侧脑室注射辣椒素(Cap)或SP抗血清对SRBC免疫反应均无明显影响。提示免疫反应能影响下丘脑、海马及脑桥SP的代谢,进一步说明了不仅神经系统能够调节免疫系统的功能,反过来免疫系统也能够影响神经系统的活动。
The neuroimmunomodulation (NIM) function of substance P (SP) in some brain areas of rats was investigated by the hemolytic plaque-forming cell (PFC) technique for detecting humoral immune function, and by radioimmunoassay for assessing SP content in some brain areas. The results showed that the contents of SP in the hypothalamus, hippocampus and pons were significantly decreased, while SP contents in the hypophysis, midbrain and medulla were not significantly changed at the peak of the immune response to sheep red blood cells (SRBC). Intracerebroventricular injection of capsaicin and SP antiserum had no effect on the immune response to SRBC. These results suggest that the immune response could affect the metabolism of SP in some brain areas, and provide further evidence that the nervous system (NS) can both regulate immune function and be affected by it.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1993年第6期417-421,共5页
Acta Academiae Medicinae Sinicae
关键词
免疫反应
脑
P物质
immune response
brain
substance P
