摘要
在 12例稳定、无腹膜炎的持续性非卧床腹膜透析 (CAPD)住院病人中 ,观察硝普钠和摇摆对腹膜透析病人溶质转运的影响。分别计算标准腹膜平衡试验 (PET)中尿素氮、肌酐的 4h清除率以及溶质面积转运系数 (MTAC) ,记录当天总引流量 ,并测定引流液中总蛋白、白蛋白、免疫球蛋白G的含量。结果表明 ,硝普钠和摇摆均能增加腹膜透析时小分子溶质转运 ,摇摆对腹膜透析时大分子蛋白质丢失的影响较硝普钠小。提示腹膜透析时适当活动可以提高对小分子溶质的清除而不影响大分子蛋白的丢失。
To explore the relationship between peritoneal transport of solutes and permeability of the peritoneum capillary as well as peritoneal stagnant fluid layer within dwell time, we observed the effects of nitroprusside and vibration on peritoneal transport of solutes in continuous ambulatory peritoneal dialysis(CAPD) patients. Twelve stable, routine CAPD patients were involved, who had no peritonitis for at least 4 weeks before the test. Standard peritoneal equilibrium tests(PETs) were performed, and mass transfer area coefficiency(MTAC) were calculated after adding nitroprusside to the dialysate or vibrating the patients's peritoneum. The concentrations of total protein, albumin and immunity globulin G in total drained dialysate were examined, and total drained volumes were recorded. Compared with the control, the MTACs value of BUN, Creatinine(Cr) increased significantly both in the nitroprusside group and vibration group(P<0.05); the concentration of immunoglobin G in the total drained fluid was higher in the nitroprusside group than that in the control(P<0.05); However, there was no significant difference in the total drained volume among the three groups. We conclude that nitroprusside and vibration can increase the peritoneal transport of small molecular solutes, and vibration has less influence on the loss of protein in CAPD. It suggests that moderated movement may improve the removal of the small molecules in CAPD patients. [
出处
《湖南医科大学学报》
CSCD
2000年第4期357-360,共4页
Bulletin of Hunan Medical University
关键词
腹膜透析
肾疾病
硝普钠
摇摆
溶质转运
peritoneal dialysis
kidney disease
sodium nitroprusside
vibration *
mass trans port *
