摘要
本文试用氮咪青霉素(mecillinam)及氟哌酸(norfloxacin)治疗15例经治不愈的耐药性伤寒患者。其中13例为二药联合治疗,另二例分别为氮(艹卓)咪青霉素及氟哌酸单独治疗。13例联合治疗者平均4.8天退热,3天肠出血停止,3.1天中毒性肠麻痹消失。4天中毒状态消失。停药后大便培养均三次阴性,治疗后血嗜酸性粒细胞计数均从零上升到正常。疗效满意。15例中3例复发。联合疗法疗程达2～3周者无一例复发。本文为伤寒耐药菌种感染者的治疗提供了切实有效的方法。
We treated 15 patients with typhoid fever in which the causative germs were resistant to chloromycetin, ampicillin, amoxicillin and SMZco. 13 patients were treated by combined therapy using mecillinam and norfloxacin, one patient was only freated with mecillinam 0.8gm every eight hours intravenously, and another one patient was only treated with norfloxacin 0.3gm every six hours by mouth. In the 13 patients receiving combined therapy, the high fever underwent lysis to normal within an average of 4.8 days, gastroenteric fleeding stopped within an average of 3.1 days,and paralyic ileus disappeared within 3.1 days. The typhoid toxic state disappeared within 4 days. After the drugs were dis continued, fecal typhoid bacillus culture became negative in all 15 patients and blood EOS count rose from zero to normal, 3 patients (20%) had one relapse. None of the patients with two drugs for 2—3 weeks were relapse. It was concluded that antibiotic combined therapy was effective for patients suffering from typhoid caused by resistant strains.
出处
《上海第二医科大学学报》
CSCD
1989年第1期38-40,共3页
Acta Universitatis Medicinalis Secondae Shanghai
