摘要
目的 :研究 6 -羟基多巴胺 (6 - OHDA)诱发的大鼠帕金森 (PD)模型 GNDF表达。方法 :通过脑内立体定向术注射 6 -羟基多巴胺建立大鼠 PD模型。采用免疫组化的方法观察损伤侧脑胶质细胞源性神经营养因子 (GDNF)表达。结果 :6 - OHDA诱发的 PD鼠 GDNF蛋白表达减低 (P <0 . 0 5 )。结论 :神经营养因子表达减少可能是 6 - OHDA诱发的
Objective:To investigate the expression of GDNF in PD rats induced by 6 OHDA Methods:Expression of GDNF was examined by using immunochemistry method after 6 OHDA injecting stereoscopically to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) of rats Result:Expression of GDNF decreased in PD rats (P<0 05) Conclusion:Reduction of GDNF expression may be involved in the pathogenesis of PD induced by 6 OHDA in rats
出处
《广西医科大学学报》
CAS
2001年第2期194-195,共2页
Journal of Guangxi Medical University
