摘要
（1）现察74名PA、TDI、Pt作业工人的健康状况。并以80名正常人为对照，进行放射免疫吸附试验(RIST)谢定血中总IgE含量；用放射变应原吸附试验（RAST)测定抗原特异性IgE(S—IgE)含量。发现仅2名Pt作业工人有症状者总IgE有增高趋势；而PAST在各作业工人中哮喘者明显增高。其CMP值阳性率对PA、TDI．Pt哮喘者分别为90％、100％、
Etiologic and diagnostic studies on severalrepresentative occupational asthma were car-ried out. It included low molecular chemicalagents such as phthalic anhydride (PA),toluene diisocyanate (TDI), ethylenediamine(EDA); biological agents such as grain dust,mushroom spore and silk etc. The clinical symptoms showed that theasthma attack was related to occupationalallergic exposure. The bronchial provocationtest of allergens (A-BPT) showed immediate,late and dual airway response. The skin test(ST),specific IgE, specific IgG against corresp-onding antigen usually showed positive results.The antigenic specific detective techniqueswere important means for etiologic diagnsis. Different experimental asthmatic modelwere reproduced by corresponding antigenicconjugates immunization. The bronchia Ispasm,airways obstruction, positive specific IgE andIgG as well as increased level of immunemediator were found by Tc-99m-DTPA inha-lation, PCA and radioimmunity experimentaltechniques. The major pathological features of thelungs in asthmatic animals were mucus plug-ging of the bronchi and bronchioles, denuda-tion of the bronchial epithelium, and eosino-phils infiltration. These results suggested that an immunol-ogic mechanism might be involved in all ofthese asthmatic findings of both clinical andexperimental studies.
出处
《中国工业医学杂志》
CAS
1991年第2期12-15,共4页
Chinese Journal of Industrial Medicine
