摘要
应用原位杂交技术检测了U937细胞c-fos 基因表达水平。检测结果指出,TPA 所诱导的c-fos mRNA 表达具有明显的剂量效应关系。同时尚证实GM-CSF,TNF,IL-9,IL-3,IL-6可诱导增加U937细胞c-fos 基因的表达,其中以GM-CSF、TNF 的作用最强。
The levels of c-fos mRNA in U937 cell line were determined with in situ hybridization.Theresults showed that TPA induced the expression of c-fos gene with a relationship of dosage-ef-fect.It was also proved that GM-CSF,TNF,IL-9,IL-3 and IL-6 increased the expression of c-fos gene.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1993年第6期332-335,共4页
Chinese Journal of Immunology
关键词
原位杂交
癌基因
细胞因子
In situ hybridization
Oncogene
Cytokine
