摘要
目的 分析尿毒症血液透析(HD)患者血脂变化的原因.方法 测定54例尿毒症血液透析患者血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白(apo)AI及B的含量,与30例正常人进行对照研究.结果 患者组透析前、后的血TG、LDL、HDL、apoAI及apoB含量与对照组相比均有显著差异(p<0.01),而尿毒症患者组透析前、后的血清脂质含量相比无明显差异p>0.05.结论 尿毒症时脂质代谢发生紊乱,是促进动脉粥样硬化、缺血性心、脑血管损害的重要原因,HD不能纠正其代谢紊乱,也不能降低心、脑血管疾病的发病率.
ve To analyse the causes of changes of serous lipids of uremic patients after hemodialysis.Methods The contents of TG, TC, LDL, HDL, apoAI and apoB of 54 cases of uremia were determined afterhemodialysis. The results of blood samples of 30 cases of normal subjects were used as controlled group. ResultsThe results of therapeutic group showed significant difference (P < 0. 01 ) compared with the ones of controlled grouppre-and post-hemodialysis. Conclusion Metabolic disturbance of lipids during uremia is the reasons for arterialselerosis, ischemic cardio-cerebrovascular diseases, and hemodialysis cannot correct the metabolic disturbance ofuremic patients and cannot reduce the morbidity of cardiovascular diseases.
