摘要
应用免疫组化 S- P方法检测 78例直肠癌手术标本中 FAK的表达情况。结果示直肠癌原发灶 FAK表达阳性率为 79.49% ,其中无区域淋巴结转移者阳性率为 6 0 .71% ,有区域淋巴结转移者阳性率为 90 % (P<0 .0 1) ,FAK表达水平与直肠癌浸润深度和 Dukes′分期呈正相关 (P<0 .0 1,P<0 .0 1)。FAK阳性者术后 3年、 5年生存率分别为 44 .4%、 33.99%。而阴性者为 88.2 4%、 82 .35 % ,二组均有显著性意义 (P<0 .0 1,P<0 .0 1)。认为直肠癌由于 FAK增加 ,加速了恶性细胞的增殖、浸润和转移 ;检测直肠癌组织中 FAK表达状况 ,有助于进一步了解直肠癌生物学行为和预后判断。
The expression of FAK was examined immunohistochemically in resected rectal carcinoma,using anti monoclonal antibody.The results showed 78 patients tested,79.49% were positive staining of FAK in the primary lesions,while others(20.51%) were negative.Tumors with regional nodal metastasis showed significantly higher positive staining rate than those without nodal involvement.FAK expression is correlated with tumor invasion(P<0.01) or the progression of Dukes stage(P<0.01).Survival rate at 3 and 5 years was 44.4% and 33.99% respectively for positive staining group of FAK,compared to 88.24% and 82.35% respectively for negative staining group(P<0.01).The data indicated that FAK increased proliferation,invasion and metastasis.The expression of FAK may be a useful tool for prognosis of human rectal carcinoma.
出处
《山东医药》
CAS
北大核心
2001年第12期7-8,共2页
Shandong Medical Journal
