摘要
对193名二硫化碳(CS_2)作业工人和50名不接触CS_2及其他毒物者(对照组)进行调查。结果发现CS_2作业工人尿β_2-MG、Alb含量及尿AKP、LDH、γ-GT活性较对照组显著升高,且随接触CS_2浓度增高、工龄延长而升高明显,呈剂量-反应关系。若以超过对照组95％上限值为阳性标准,则尿β_3-MG、AKP、LDH阳性率增高有显著意义。表明长期接触CS_2可引起作业工人肾小管和肾小球的混合性损伤。提示尿β_2-MG、AKP、LDH可作为慢性CS_2肾损伤的早期监测指标。
193 workers exposed to CS_2 workers and 50 nonexposed healthy persons as controlswere investigated. Results showed that thelevels of Urinaria β_2-microglobulin(β_2 MG),albumin(Alb), alkaline phosphatase (AKP),lactate dehydrogenase (LDH) and γ-glutamytranspeptidase (γ-GT) in the exposed groupwere significantly hingher than that of thecontrol and increased progressively with ince-asing working years and concentration ofCS_2. If higher than the 95th percentile ofvalues found in the control group used ascriteria of significance, the abnormal prevel-ence of urinary β_2-MG, AKP, LDH in exp-osed group were significantly increased, Itis suggested that CS_2 may cause a mixedproximal tubular and glomerular damage.Changes of urinary β_2-MG level and AKP,LDH activity may be a valuable index forearly detection of chronic renaldamage inCS_2 workers.
出处
《中国工业医学杂志》
CAS
1993年第4期208-211,共4页
Chinese Journal of Industrial Medicine
关键词
二硫化碳
肾损伤
职业中毒
毒性
carbon disulfide (CS_2)
β_2-microglobulin(β_2-MG)
urinary enzyme
renal lesion
