摘要
24例老年高血压病 期患者 ,服用硝苯啶 4年以上。服药前经超声心动图检查 ,证实有左室肥厚。服药 2年后 ,收缩压、舒张压、左室重量 (L VM)与左室重量指数 (L VMI)都有显著的降低 ,左室收缩与舒张功能有所改善。服药 4年后 ,收缩压与舒张压继续有所下降 ,但 L VM与 L VMI有所回升 ,与治疗前相比 ,则无显著差异。表明经硝苯啶 4年治疗 ,左室肥厚程度保持原有水平 。
Twenty four elderly patients with phase Ⅱ hypertension received nifedipine over 4 years,the dose being from 10 mg to 30 mg tid.Before receiving nifedipine,all the patients were demonstrated to have left ventricular hypertrophy by UCG.After 2 years′treatment of nifedipine,there was a significant decrease in SBP,DBP,LVM,LVMI,FS% and EFV.After 4 years of nifedipine treatment,SBP and DBP reduced continuously,while LVM and LVMI,compared with that of pre treatment,showed no significant difference,though increased somewhat,This suggests that the left ventricular hypertrophy is kept at the pretreatment level for 4 years of nifedipine treatment and the left ventricular systolic and diastolic function has further improved.
关键词
硝苯啶
高血压
心室肥厚
老年人
nifedipine
elderly hypertension
left ventricular hypertrophy regressiove effect
