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竹叶椒抑制血小板活化因子(PAF)的活性成分 被引量:6

The active constituents of platelet-activating factor (PAF) inhibitors from Zanthoxylum planispinum Sieb. et Zucc.
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摘要 自芸香科花椒属植物竹叶椒(Zanthoxglum planispinum Sieb.et Zucc)根和茎的石油醚及二氯甲烷提取物中分离得到5个化合物(I~V),经物理常数测定,光谱(UV,IR,HNMR,MS)分析分别鉴定,Ⅰ为β-香木脂醇,Ⅱ为β-谷甾醇,Ⅲ为L-细辛脂素,Ⅳ为L-竹叶椒脂素,V为花椒明碱。其中Ⅲ,IV,V具有抑制PAF聚集的活性,以Ⅳ活性最强,Ⅲ次之,V较弱。花椒明碱首次从该植物中分离得到。 Five compounds were isolated from the petroleum ether and methylene chloride extracts of the roots and stems of Zanthoxylum planispinum Sieb. et Zucc. (Rutaceae). The structure of these compounds were determined on the basis of physical constant and UV, IR, ~1HNMR, MS spectral analysis. They are β-amyrin ( I ) , β-sitosterol ( Ⅱ ) , L-asarinin ( I ) , L-planinin ( IV ) and zanthobungeanine ( V ) respectively. Compound I 、 IV 、 V showed obviously inhibitoryactivity to platelet aggregation caused by PAF, among them compound Ⅲ was less active than compound V , compound V was the least. Zanthobungeanine was isolated for the first time from this plant.
出处 《植物资源与环境》 CSCD 1993年第2期25-27,共3页 Journal of Plant Resources and Environment
基金 天然药物及仿生药物国家重点实验室资助课题
关键词 竹叶椒 血小板 活性物质 Zanthoxylum planispinum Sieb. et Zucc. L-planinin PAF
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参考文献2

  • 1陈瑾,耿桂兰,叶光华,奚凤德,陈淑凤,贺存恒,郑启泰.竹叶椒化学成分的研究[J]药学学报,1988(06).
  • 2任丽娟,谢凤指.花椒根的生物碱研究[J]药学学报,1981(09).

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