摘要
目的 :研究更年期性激素水平与胰岛素抵抗 (INS)的关系对女性冠心病发病的影响。方法 :测定更年期女性冠心病患者 46例 (Ⅰ组 )与正常对照组 (Ⅱ组 ) 4 0例的血清雌二醇 (E2 )、孕酮 (P)、睾酮 (T)、空腹胰岛素(FINS)及血脂谱。结果 :Ⅰ组E2 比Ⅱ组明显降低 (P <0 0 0 1) ,胰岛素敏感性指数 (ISI)及动脉硬化指数 (AI)Ⅰ组高于Ⅱ组 (P <0 0 0 5 ) ,而P、T值Ⅰ组与Ⅱ组相比也有降低 ,但差别无显著意义 (P >0 0 0 5 ) ,Ⅰ组的胆固醇(TC)、甘油三酯 (TG)、低密度脂蛋白 -C(LDL -C)均明显高于Ⅱ组 (P <0 0 0 1) ,高密度脂蛋白 (HDL)水平则是Ⅰ组低于Ⅱ组 (P <0 0 0 1)。线相关分析表明E2 与ISI、AI、TC、TG呈负相关 ,E2 与HDL水平呈正相关。结论 :提示更年期女性冠心病患者性激素的紊乱与体内的INS、AI、脂质等危险因素存在密切相关性 。
Objective: To study the relationship between the sex hormone levels and insulin resistance(INS) and observe their effects on climacteric women with coronary heart disease(CHD). Methods: The serum concentrations of estradiol(E 2), pregnendione(P), testosterone(T),and fasting insulin(FINS) as well as the lipid spectrum were measured in 46 climacteric female patients with CHD (group Ⅰ) and in 40 normal controls (group Ⅱ). Results: The serum concentration of E 2 in group Ⅰ was significantly lower than that in group Ⅱ(P<0 001). The insulin sensibility index (ISI) and arteriosclerosis index(AI) in group Ⅰwere higher than those in group Ⅱ(P<0 05).The serum concentrations of cholesterol(TC), triglyceridex(TG) and low density lipoprotein cholesterol(LDL-C) were significantly higher in group Ⅰ(all P<0 01) than those in group Ⅱ. The serum level of high density lipoprotein(HDL) was lower in group Ⅰ(P<0 01) than that in group Ⅱ. There was a significant negative correlation between E 2 and ISI,AI,TC and TG in terms of their serum levels while a positive correlation existed between the E 2 and HDL levels. Conclusion: There is a close relationship between the sex hormone disorder and the dangerous factors of INS and AI in climacteric famale patients with CHD . It possibly correlates with a higher incidence of CHD.
出处
《贵阳医学院学报》
CAS
2001年第4期305-307,共3页
Journal of Guiyang Medical College
