摘要
目的观察颈部硬膜外预先注射吗啡、氟哌利多对全喉切除患者术后的镇痛效果及安全性。方法择期行全喉切除术的男性喉癌患者40例，ASAⅠ～Ⅱ级，随机分为超前镇痛组(P组)和对照组(C组)，每组20例。P组患者在术前硬膜外隙注入吗啡2mg、氟哌利多5mg，用生理盐水稀释到容量为6ml。C组只注射生理盐水6ml。观察并记录术前及术后1、2、8、12、24h各时间点的镇痛评分(VAS)、镇静评分、平均动脉压(MAP)、脉搏(P)、呼吸频率(RR)、脉搏血氧饱和度(SpO2)及不良反应。结果P组患者术后24h内VAS评分明显低于C组(P<0．01)；P组MAP、P、RR、SpO2术后变化不明显，与C组相比无明显差异。结论颈部硬膜外吗啡复合氟哌利多超前镇痛用于全喉切除术，镇痛效果确切，且对生命体征无明显影响。
Objective To investigate the effects of preemptive cervical epidural morphine/droperidol mixture for the pain after laryngectomy. Methods Forty patients scheduled to undergo laryngectomy were randomly divided into 2 groups: preemptive group (P) and control group (C). Morphine 2 mg and droperidol 5 mg in 6 ml of saline was administered epidurally before the induction of general anesthesia in group P, with 6ml of saline given in the same way in group C. Mean arterial pressure (MAP), pulse rate (P), respiratory rate (RR) and saturation of pulse oxygen (SpO 2) were monitored perioperatively. VAS (visual analogue score) and sedative score were analyzed 1, 2, 8, 12, 24 hours after the operation. Results The VAS values in group P were significantly lower than that in group C within 24 hours in the postoperative period (P<0.01), and there were no differences in vital signs between the 2 groups. Conclusion It is safe and feasible to give preemptive epidural morphine and droperidol to relieve the postoperative pain after laryngectomy.
出处
《徐州医学院学报》
CAS
2003年第3期214-216,共3页
Acta Academiae Medicinae Xuzhou
关键词
全喉切除
超前镇痛
吗啡
氟哌利多
颈部硬膜外
analgesia, preemptive, cervical epidural
morphine
droperidol
laryngectomy
