摘要
观察米索前列醇(Mis)、米非司酮(Mif)及2药合用对大、小鼠的抗早孕作用。单用Mis,其抗早孕作用弱,且无量-效关系。Mif单用及与Mis 200,400和800μg/kg合用时大鼠的半数有效量(ED_(50))依次为959,635,477和195μg/kg;小鼠的ED_(50)依次为486,315,249和98μg/kg。提示Mis可剂量依赖性增强不同剂量Mif的抗早孕作用。
Terminations of early pregnancy induced by misoprostol (Mis) and mifepristone (Mif) alone or in combination were studied in rats and mice. The effect of Mis alone on early pregnancy interruption was less effective than that of combination, and not in a dose-dependent fashion. The ED50 for Mif alone and in combination with Mis 200, 400 and 800 Ag/kg were 959, 635, 477 and 195 g/kg in rats, and 486, 315, 249 and 98 g/kg in mice, respectively. The results suggest that Mis potentiates Mif-induced interruption of early pregnancy in rats and mice.
出处
《新药与临床》
CSCD
北大核心
1993年第6期330-332,共3页
关键词
米索前列醇
米非司酮
流产
misoprostol mifepristone
abortion
combination drng therapy
